Plos Biology - MACC1 (Metastasis Associated in Colon Cancer 1) is a prognostic biomarker for cancer progression and metastasis in a large variety of solid tumor types, particularly colorectal cancer.

A team of German scientists discovered two small molecules, Lovastatin and Rottlerin, which are the most potent MACC1 transcriptional inhibitors. Experiments on mice affected by colorectal cancer showed that Lovastatin and Rottlerin could produce promising results, especially in the treatment of liver metastasis. This new discovery might be of therapeutic value for colorectal cancer patients.

 

Statin and Rottlerin small-molecule inhibitors restrict colon cancer progression and metastasis via MACC1

 

Authors: Manisha Juneja , Dennis Kobelt , Wolfgang Walther, Cynthia Voss, Janice Smith, Edgar Specker, Martin Neuenschwander, Björn-Oliver Gohlke, Mathias Dahlmann, Silke Radetzki, Robert Preissner, Jens Peter von Kries, Peter Michael Schlag, Ulrike Stein

Plos Biology - https://doi.org/10.1371/journal.pbio.2000784  - June 1, 2017