Cell Death & Disease - A research led by group of American scientists demonstrated that DNA-damaged Lgr5⁺ stem cells are particularly susceptible to external dietary cues, providing a therapeutic strategy for eliminating damaged Lgr5⁺ stem cells to reduce colon cancer initiation.

 

Rapidly cycling Lgr5+ stem cells are exquisitely sensitive to extrinsic dietary factors that modulate colon cancer risk

 

Authors: Kim E, Davidson LA, Zoh RS, Hensel ME, Salinas ML, Patil BS, Jayaprakasha GK, Callaway ES, Allred CD, Turner ND, Weeks BR, Chapkin RS.

 

Cell Death and Disease (2016) 7, e2460; doi:10.1038/cddis.2016.269. Published online 10 November 2016