Gastroenterology - A study conducted by a team of Korean scientists shows that through the activation ofYAP1 activities and a positive signaling loop, PGE2 promotes proliferation of colon cancer cell lines and colon tissue regeneration in mice with colitis.

 

Prostaglandin E2 Activates YAP and a Positive-signaling Loop to Promote Colon Regeneration Following Colitis but Also Carcinogenesis in Mice

 

Authors: Kim HB, Kim M, Park YS, Park I, Kim T, Yang SY, Cho CJ, Hwang D, Jung JH, Markowitz SD, Hwang SW, Yang SK, Lim DS, Myung SJ

 

Gastroenterology. 2016 Nov 15. pii: S0016-5085(16)35347-1. doi: 10.1053/j.gastro.2016.11.005.