Nature Communications - SNHG5 promotes tumour cell survival in colorectal cancer through blocking the action of STAU1. A team of Danish and French researchers discovered that depletion of SNHG5 causes tumor cell death in vitro and limits tumour growth in vivo.

 

SNHG5 promotes colorectal cancer cell survival by counteracting STAU1-mediated mRNA destabilization

 

Authors: Nkerorema Djodji Damas, Michela Marcatti, Christophe Côme, Lise Lotte Christensen, Morten Muhlig Nielsen, Roland Baumgartner, Helene Maria Gylling, Giulia Maglieri, Carsten Friis Rundsten, Stefan E. Seemann, Nicolas Rapin, Simon Thézenas, Søren Vang, Torben Ørntoft, Claus Lindbjerg Andersen, Jakob Skou Pedersen & Anders H. Lund

Nature Communications 7 - doi:10.1038/ncomms13875 - 22 December 2016