Cell Stem Cell - A team of Dutch scientists discovered that disabling intestinal stem cells proliferation triggers their differentiation into hormone-producing enteroendocrine cells. This discovery allows researchers to better understand the operating mechanisms of intestinal stem cells and how they are disrupted by the development of cancer.

 

Induced Quiescence of Lgr5+ Stem Cells in Intestinal Organoids Enables Differentiation of Hormone-Producing Enteroendocrine Cells

 

Authors: Onur Basak, Joep Beumer, Kay Wiebrands, Hiroshi Seno, Alexander van Oudenaarden, Hans Clevers.

 

Cell Stem Cell, DOI: http://dx.doi.org/10.1016/j.stem.2016.11.001, December 8, 2016