Nature Communications - VGLL4 is downregulated in colorectal cancer patients and it is positively associated with patient survival rate and inversely correlated with the espression of Wnt genes. VGLL4 regulates both Wnt and Hippo signaling by targeting the TCF4-TEAD4 complex.

 

VGLL4 targets a TCF4–TEAD4 complex to coregulate Wnt and Hippo signalling in colorectal cancer

 

Authors: Shi Jiao, Chuanchuan Li, Qian Hao, Haofei Miao, Lei Zhang, Lin Li & Zhaocai Zhou

Nature Communications 8 - doi:10.1038/ncomms14058 - 04 January 2017