Nature Communications - The development of cancer is closely associated with the accumulation of epigenetic changes that alter chromatin structure and lead to dysregulated gene expression. The study suggests that the CRC epigenome is defined by highly recurrent epigenetic alterations at enhancers which activate a common, aberrant transcriptional programme critical for CRC growth and survival.

 

Hotspots of aberrant enhancer activity punctuate the colorectal cancer epigenome

 

Authors: Andrea J. Cohen, Alina Saiakhova, Olivia Corradin, Jennifer M. Luppino, Katreya Lovrenert, Cynthia F. Bartels, James J. Morrow, Stephen C. Mack, Gursimran Dhillon, Lydia Beard, Lois Myeroff, Matthew F. Kalady, Joseph Willis, James E. Bradner, Ruth A. Keri, Nathan A. Berger, Shondra M. Pruett-Miller, Sanford D. Markowitz & Peter C. Scacheri

Nature Communications 8 - doi:10.1038/ncomms14400 - 07 February 2017