Nature Communications - A team of American researchers has demonstrated that high-fat diet can alter not only the function of intestinal stem and progenitor cells, but also their capacity to initiate tumours.

 

High-fat diet enhances stemness and tumorigenicity of intestinal progenitors

 

Authors: Semir Beyaz, Miyeko D. Mana, Jatin Roper, Dmitriy Kedrin, Assieh Saadatpour, Sue-Jean Hong, Khristian E. Bauer-Rowe, Michael E. Xifaras, Adam Akkad, Erika Arias, Luca Pinello, Yarden Katz, Shweta Shinagare, Monther Abu-Remaileh, Maria M. Mihaylova, Dudley W. Lamming, Rizkullah Dogum, Guoji Guo, George W. Bell, Martin Selig, G. Petur Nielsen, Nitin Gupta, Cristina R. Ferrone, Vikram Deshpande, Guo-Cheng Yuan, Stuart H. Orkin, David M. Sabatini & Ömer H. Yilmaz          

 

Nature 531, 53–58 (03 March 2016) doi:10.1038/nature17173. Published online 02 March 2016