Nature Communications - An individual’s risk to develop colorectal cancer (CRC) is affected by a broad spectrum of genetic variants which contribute to disease onset and progression. The study shows that variant rs1800734 promotes cancer malignancy by enhancing expression of particular genes

 

The non-coding variant rs1800734 enhances DCLK3 expression through long-range interaction and promotes colorectal cancer progression

 

Authors: NingQingLiu, Menno ter Huurne, Luan N. Nguyen, TianranPeng, Shuang-Yin Wang, James B. Studd, OnkarJoshi, HalitOngen, Jesper B Bramsen, JianYan, Claus L. Andersen, JussiTaipale, Emmanouil T. Dermitzakis, Richard S. Houlston, Nina C. Hubner &Hendrik G. Stunnenberg

Nature Communications 8 - doi:10.1038/ncomms14418 – 14 February 2017