Gastroenterology - Nearly 20% of the global cancer burden can be linked to infectious agents. It is still not clear how these agents influence tumor formation. However, a group of Chinese researchers examined colorectal carcinogenesis in mice and noticed that infection of CRC cells with F nucleatum increases their proliferation, invasive activity, and reduces survival times.

 

Fusobacterium nucleatum Increases Proliferation of Colorectal Cancer Cells and Tumor Development in Mice by Activating TLR4 Signaling to NFκB, Upregulating Expression of microRNA-21

 

Authors: Yang Y, Weng W, Peng J, Hong L, Yang L, Toiyama Y, Gao R, Liu M, Yin M, Pan C, Li H, Guo B, Zhu Q, Wei Q, Moyer MP, Wang P, Cai S, Goel A, Qin H, Ma Y.

 

Gastroenterology 2016 Nov 19. pii: S0016-5085(16)35387-2. doi: 10.1053/j.gastro.2016.11.018