Epithelial-derived extracellular vesicles maintain intestinal tract immune balance
Nature Communications - A Chinese group of experts has discovered that EpCAM-dependent extracellular vesicles produced by intestinal epithelial cells have a protective effect and participate in maintaining the intestinal tract immune balance.
EpCAM-dependent extracellular vesicles from intestinal epithelial cells maintain intestinal tract immune balance
Authors: Lingling Jiang, Yingying Shen, Danfeng Guo, Diya Yang, Jiajun Liu, Xuefeng Fei, Yunshan Yang, Buyi Zhang, Zhendong Lin, Fei Yang, Xiaojian Wang, Keyi Wang, Jianli Wang & Zhijian Cai.
Nature Communications 7, Article number:13045 (2016), doi:10.1038/ncomms13045. Published:10 October 2016
Abstract:
How the intestinal tract develops a tolerance to foreign antigens is still largely unknown. Here we report that extracellular vesicles (EVs) with TGF-β1-dependent immunosuppressive activity are produced by intestinal epithelial cells (IECs) under physiological conditions. Transfer of these EVs into inflammatory bowel disease (IBD) mice induced by dextran sulfate sodium salt decreases IBD severity by inducing regulatory T cells and immunosuppressive dendritic cells. In contrast, decreased endogenous EV production promotes IBD development. IECs produce EVs with increased levels of TGF-β1 upon IBD development in an ERK-dependent manner. Furthermore, these EVs tend to localize in the intestinal tract associated with epithelial cell adhesion molecule (EpCAM). Knockdown of EpCAM in vivo increases the severity of murine IBD, and the protective effect of EVs from IECs with decreased EpCAM on murine IBD is blunted. Therefore, our study indicates that EVs from IECs participate in maintaining the intestinal tract immune balance.
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