Cancer Research - Scientists demonstrated that Mcl-1 protein is often degraded in cancer cells subjected to effective therapeutic treatment, and this degradation has been associated with intrinsic and acquired drug resistance.

This study shows that Mcl-1 participates directly in determining effective therapeutic responses in colon cancer cells, providing new insights into fundamental mechanisms of drug resistance.  

 

Mcl-1 Degradation Is Required for Targeted Therapeutics to Eradicate Colon Cancer Cells

 

Authors: Jingshan Tong, Peng Wang, Shuai Tan, Dongshi Chen, Zaneta Nikolovska-Coleska, Fangdong Zou, Jian Yu and Lin Zhang

Cancer Res -  DOI:10.1158/0008-5472.CAN-16-3242 – 1 May 2017